Deformation-based morphometry (DBM) is a method for identifying macroscopic anatomical differences among the brains of different populations of subjects. The method involves spatially normalising the structural MR images of a number of subjects so that they all conform to the same stereotactic space. Multivariate statistics are then applied to the parameters describing the estimated nonlinear deformations that ensue. To illustrate the method, the gross morphometry of male and female subjects are compared. Brain asymmetry, the effect of handedness, and the interactions among these effects are also assessed.
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